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TRADITIONAL CHINESE MEDICINE


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Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome.​

Zhenzhong L, Xiaojun Y, Weijun T, Yuehua C, Jie S, Jimeng Z, Anqi W, Chunhui B, Yin S.
Abstract

OBJECTIVE:To compare the impacts of electroacupuncture (EA) and moxibustion (Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P (SP) and vasoactive intestinal peptide (VIP) in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome (IBS-D and IBS-C, respectively).

METHODS:Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli (ST 36) and Shangjuxu (ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions, a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases, leaving 81 participants (41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy, sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.

RESULTS:Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However, Mox was more effective at reducing diarrhea in IBS-D patients, whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa, with no significant difference shown between the two treatments.

CONCLUSION:Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients.


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DERUN CLINIC

144 S. Federal Highway, Boca Raton, FL, 33432

derunclinicllc@gmail.com

​561-609-9555
Contact Information:
​DERUN CLINIC
Address: 144 S Federal Hwy
Boca Raton, FL 33432
Phone: (561) 609-9555
Fax: (561) 370-6108
Email: derunclinicllc@gmail.com
​Hours:
Monday: CLOSED
Tuesday: 1pm - 6pm
Wednesday: 1pm - 6pm
Thursday: 1pm - 6pm
Friday: 1pm - 6pm
Saturday: 1pm - 6pm
Sunday: CLOSED
Contact Information:
ACUPUNCTURE DERUN CLINIC
​Address: 
5130 Linton Blvd # A2
Delray Beach, FL 33484
Phone: (561) 779-8888
Fax: (561) 370-6108
Email: derundelray@gmail.com
​
Hours:
Monday: CLOSED
Tuesday: 8am - 12pm
Wednesday: 8am - 12pm
Thursday: 8am - 12pm
Friday: 8am - 12pm
Saturday: 8am - 12pm
Sunday: CLOSED

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  • Home
    • About Us
    • Doctor Introduction
    • Contact Us
  • Patient Care & Health Info
    • What is Acupuncture?
    • What are Chinese Herbs?
    • Treatable Conditions
    • Services
  • Videos & Publications
    • Patient Videos
    • Publications
  • Herbal Formulas